Meanwhile, although there is evidence that anti‐TNF‐α reduces the levels of amyloid plaques and tau phosphorylation,223 a study argues against long‐term use of pan‐anti‐TNF‐α inhibitors in AD, owing to the importance of intact TNF‐α receptor signaling for microglial‐mediated uptake of extracellular Aβ peptide pools.224. Here, TNF is linked to Alzheimer disease.