MAPT and Alzheimer disease: Meanwhile, although there is evidence that anti‐TNF‐α reduces the levels of amyloid plaques and tau phosphorylation,223 a study argues against long‐term use of pan‐anti‐TNF‐α inhibitors in AD, owing to the importance of intact TNF‐α receptor signaling for microglial‐mediated uptake of extracellular Aβ peptide pools.224