Due to the vital role of hormones secreted by the HPO axis in preparing reproductive tissues for healthy reproduction, any dysregulation will result in impaired reproductive function, reproductive-related disorders such as premature ovarian failure (POF), polycystic ovarian syndrome (PCOS), ovarian and uterine cancer, endometriosis, etc., and consequently infertility [21][22][23]. Here, GFER is linked to polycystic ovary syndrome.