4%); (2) compared with patients without anxiety, patients with anxiety had more severe depression, higher positive symptom score, higher TSH, A-TG and A-TPO levels, higher blood pressure, higher blood glucose levels, and were more likely to have psychotic symptoms and suicide attempts; and (3) there were gender differences in the correlation between anxiety symptoms and demographic and clinical variables in patients with FEDN MDD. The gene discussed is TPO; the disease is major depressive disorder.