In a multicenter study of 274 adult patients with positive AQP4 antibodies and 107 adult patients positive for MOG antibodies in South Korea, 41 (14.9%) AQP4-positive patients had the first symptom of APS, and 47 (17.2%) exhibited APS during the disease, while no patient positive for MOG antibodies had the first symptoms of APS, and only 2 (1.9%) patients exhibited APS symptoms during the disease (13). This evidence concerns the gene AQP4 and autoimmune polyendocrinopathy.