Furthermore, although BRD4-S is frequently defined as a tumor-promoting protein, while BRD4-L is described as a tumor-suppressor based on studies evaluating tumor growth and metastatic potential [9, 21, 23, 25, 26], there is scarcity of studies interrogating the response to chemotherapy of tumors overexpressing respective BRD4 isoforms. The gene discussed is BRD4; the disease is neoplasm.