Th2 cells produce IL-4 and IL-13 driven by the transcription factor GATA3, which can not only induce macrophage polarization to the M2 phenotype but also induce TGF-β1 and collagen synthesis through the JAK-STAT signaling pathway and induce pruritus (86, 87). This evidence concerns the gene TGFB1 and Pruritus.