In conclusion, the results of this study indicate that lncRNA PTTG3P upregulates the protein expression levels of MAP2K6 and E2F1 by binding to ILF3 to maintain the mRNA stability of MAP2K6 and E2F1, while E2F1 transcriptionally upregulates lncRNA PTTG3P to form a PTTG3P/ILF3/E2F1 positive feedback loop, which in turn promotes NSCLC occurrence and metastasis (Fig. 8). This evidence concerns the gene PTTG3P and non-small cell lung carcinoma.