We also found that E2F1 knockdown significantly downregulated the expression level of PTTG3P, while E2F1 overexpression significantly upregulated the expression level of PTTG3P in NSCLC cells and stimulated the proliferation and migration of NSCLC cells, which were inhibited by PTTG3P knockdown. Here, E2F1 is linked to non-small cell lung carcinoma.