Collectively, this study provides mechanistic insights into the roles of lncRNA PTTG3P in NSCLC, such as by forming the E2F1/PTTG3P/ILF3/MAP2K6 signaling axis and a positive feedback loop between PTTG3P and E2F1 (Fig. 8). This evidence concerns the gene E2F1 and non-small cell lung carcinoma.