Sirt3 was reported to be involved in the UPRmt in cancer cells 25, and increased Sirt3 expression was associated with the upregulation of UPRmt-related genes such as the caseinolytic mitochondrial matrix peptide proteolytic subunit (CLPP), 60-kDa heat shock protein (HSP60) and Lon peptidase 1 (LONP1) in breast cancer 26. This evidence concerns the gene SIRT3 and cancer.