A total of 8 BPH-specific genes have been screened in our study, including ALCAM, COL6A2, CRISP2, FOXF2, IGF1, PTN, SCN7A, and UAP1. Some previous studies have reported their effects on the pathology of some diseases, which mainly focused on prostate cancer. The gene discussed is CRISP2; the disease is Familial prostate cancer.