Additionally, FOXC2 exerts multiple functions on malignant progression of cancer14, 18-20, for example, FOXC2 nuclear localization inhibits E-cadherin expression, and enhances the expression level of α-SMA, vimentin to promote epithelial-mesenchymal transition (EMT) and metastasis of breast cancer cells21. This evidence concerns the gene FOXC2 and breast cancer.