Since PTGS2/COX2-PGE2 signaling cascade has been widely shown to play a fundamental role within immune cells 30, 31, 33, 34, 36, 37, exploring the potential interaction (especially between pancreatic beta cells and immune cell types) and outcomes upon modulation of this signaling axis could be a promising strategy to find new therapies to treat T1DM. Here, PTGS2 is linked to type 1 diabetes mellitus.