Remarkably, Ptgs2/Cox2-induced expression and PGE2 production in islet beta cells was shown to promote hyperglycaemia in vivo, in transgenic mice overexpressing Ptgs2/Cox2 and Prostaglandin E Synthase (Pges) in beta cells under the rat insulin promoter (RIP). The gene discussed is PTGS2; the disease is Hyperglycemia.