IKBKB and acute lymphoblastic leukemia: In 2016, Wu et al. reported its anticancer activity towards acute lymphoblastic leukemia, and revealed its mechanism involved in the binding to the ATP binding region of IKKβ as same as MG132 (an IKKβ inhibitor) through interactions of Val29, Glu97, Tyr98, Cys99, Glu100, and Gly102 142.