IKBKB and osteoporosis: Furthermore, the selective IKKβ inhibitor SC-514 inhibited the IκBα degradation to inactivate the NF-κB signal, further triggering to impair RANKL (receptor activator of nuclear factor-κB ligand)-induced osteoclastogenesis 119, which was further supported by Thummuri's study showing that inhibition of IKKβ by abietic acid attenuated RANKL-induced osteoporosis 120.