A variety of IKKβ SNPs have been reported, such as rs2272736, rs3747811, rs5029748, rs5029748, rs11986055, rs4560769, and rs6474386, and associated with the risk of hypertension, gastric and colorectal cancers, recurrent wheezing, systemic lupus erythematosus, obesity, and myelogenous leukemia 23-27. The gene discussed is IKBKB; the disease is obesity due to melanocortin 4 receptor deficiency.