SLN and hydrops fetalis: We observed the expression level of genes in Module 2 (68 genes; eg. SLN, OSR2, ACTG2, RAMP1, ACTC1) were upregulated from the initial stages of the reprogramming trajectory and highly expressed at the pseudo-time endpoint, i.e. genes mainly expressed in adult patients with HF, were primarily involved in the regulation of muscle contraction and responses to zinc and copper ions (Figure 7H).