CD4 and hydrops fetalis: However, contrary to the results reported by Zhang et al. (2023) [19]that the EAT from HF patients was enriched in immune activation-related pathways, our results showed that the immune response-related pathways (such as T cell activation) were downregulated in major immune cell types (including CD4+ and CD8+ T cells, and monocytes) of EAT from HF patients.