The interactions of BSG_PPI, HLA-DRB1_OGN, CD74_COPA, and HLA-C_FAM3C between monocyte subsets and SMCs enhanced their interactions, while CXCL8_ACKR1 weakened their interaction in the the Adults-HF group relative to the Adults-Non HF group. This evidence concerns the gene CXCL8 and hydrops fetalis.