The inhibitory communications (eg. TNF_TNFRSF1A, TNFRSF1B_GRN, CCL5_ACKR1, CD74_APP, and CXCL8_ACKR1) and enhanced communications (eg. HLA-C_FAM3C, BSG_PPIA, RPAP1_SCRT1, CCL4L2_VSIR, HLA-DRB1_OGN, and CD74_COPA) between SMCs and immune cells were widely observed, showing a disordering immune response to HF in SMCs of EAT. Here, CD74 is linked to hydrops fetalis.