Meanwhile, interactions of TNFRSF1B_GRN, CD74_APP, CCL5_ACKR1 between CD8+ T cell subtypes and SMCs were significantly weakened, and HLA-C_FAM-3C, CCL4L2_VSIR, BSG_PPIA between CD8+ T cell subtypes and SMCs were significantly enhanced in HF patients (Figure 3G). This evidence concerns the gene HLA-C and hydrops fetalis.