Chemoattractants such as MCP-1 (CCL2), MCP-3 (CCL7), SDF-1 (CXCL12), CX3CL1, POSTN, GM-CSF, M-CSF (CSF-1) and EGF produced by glioma cells actively recruit TAMs and thus promote tumor growth 68. This evidence concerns the gene CXCL12 and neoplasm.