Mutations in APP (OMIM: 104760, 21q21), PSEN1 (OMIM: 104311, 14q24), PSEN2 (OMIM: 600759, 1q42), and APOE (OMIM:107741, 19q13) which mostly follow the pattern of autosomal dominant inheritance are known to have substantial impact on AD’s vulnerability (Avramopoulos, 2009). Here, APOE is linked to Alzheimer disease.