We also have identified several other miRNAs that interact with common hub genes, suggesting their substantial roles in the initiation or progression of AD, including has-mir-27a-3p (TGFB1, ITGB1, and CXCR4), hsa-mir29b-3p (ITGB1, CXCR4, and SELE), hsa-mir-130a-3p (MYH11, TGFB1, and CXCR4), and hsa-mir-17-3p (SELE and ITGB1). These findings highlight the potential significance of miRNAs, providing insights into the molecular mechanisms underlying AD pathogenesis. This evidence concerns the gene CXCR4 and Alzheimer disease.