Next, we identified that LCN2 mRNA and protein expression was decreased following the administration of two AKT inhibitors (LY294002 and MK‐2206) in shNC HCC cells and was upregulated following the administration of an AKT activator (SC79) (Figure 4G,H; Figure S4H,I, Supporting Information). This evidence concerns the gene AKT1 and hepatocellular carcinoma.