Phosphoglycerate mutase 1 (PGAM1) is aberrantly overexpressed in various human cancers, including HCC[4] and plays a crucial role in cancer metabolism and tumor progression via its metabolic mechanism.[5] PGAM1 is primarily considered a glycolytic enzyme that catalyzes the conversion of 3‐phosphoglycerate (3‐PG) to 2‐phosphoglycerate (2‐PG) and coordinating biosynthesis pathways, including the pentose phosphate pathway and serine synthesis pathway. This evidence concerns the gene HK1 and cancer.