Reportedly, tumors in which the PI3K/AKT pathway is abnormally activated are sensitive to immunotherapy.[17, 18, 20] After the inhibition of AKT mediated by PGAM1 suppression, we confirmed that the expression of PD‐L1 in HCC was downregulated, which could promote the infiltration of CD8+ T‐cells since the inhibitory signals decreased. Here, PGAM1 is linked to hepatocellular carcinoma.