Considering the above findings, we established four HCC cell lines with recombinant LCN2 expression (Figure 4B; Figure S4B, Supporting Information), and elevated LCN2 expression rescued resistance to RSL3 and erastin, especially in shPGAM1 HCC cells (Figure 4C; Figure S4C, Supporting Information). Here, LCN2 is linked to hepatocellular carcinoma.