Phosphoglycerate mutase 1 (PGAM1) is aberrantly overexpressed in various human cancers, including HCC[4] and plays a crucial role in cancer metabolism and tumor progression via its metabolic mechanism.[5] PGAM1 is primarily considered a glycolytic enzyme that catalyzes the conversion of 3‐phosphoglycerate (3‐PG) to 2‐phosphoglycerate (2‐PG) and coordinating biosynthesis pathways, including the pentose phosphate pathway and serine synthesis pathway. The gene discussed is PGAM1; the disease is cancer.