Glucose competition between tumor cells and CTLs and accumulation of toxic metabolites (e.g., lactate) can confine CTLs under nutrient‐deficient conditions and impair their viability as well as cytotoxic function, which favors immune escape.[17, 21] In addition to this common principle, new evidence points to a critical role of ferroptosis in modifying the infiltration of immune cells and determining immunotherapeutic efficacy.[22] Here, we screened PGAM1 as a key glucometabolic gene and an independent prognostic indicator for HCC patients. Here, PGAM1 is linked to neoplasm.