To verify whether this impact on proliferation is correlated with PGAM1‐mediated ferroptosis, we tested the killing effect of two common ferroptosis inducers (RSL3 and erastin) in four HCC cell lines under high‐ and low‐glucose conditions, as a previous study indicated that tumor cells could exhibit ferroptosis resistance under glucose starvation.[13] We found that PGAM1 inhibition significantly sensitized HCC cells to two ferroptosis inducers regardless of glucose concentration. Here, PGAM1 is linked to hepatocellular carcinoma.