Sun et al. and Lin et al. have proposed that DNA abnormalities and epigenetic degeneration were present in various malignancies, including gastrointestinal tumors and LGG.11,35 In addition, the MIR155 gene was highly expressed in cholangiocarcinoma and LGG abnormally, which affected the prognosis of patients by mediating immune cell infiltration and immune checkpoint expression.36 This suggested that there may be common metabolic pathways and gene expression between gastrointestinal tumors and LGG to mediate the occurrence and development of tumors. The gene discussed is MIR155; the disease is cholangiocarcinoma.