To further explore how lncRNA BCCE4 affects T cells through the PD‐L1/PD‐1 interaction, we first incubated recombinant human PD‐1 Fc protein into EJ cells and found that the binding of PD‐1 on the bladder cancer cell surface increased as a result of lncRNA BCCE4 overexpression, whereas it was significantly decreased while UPS18 knockdown (Figure S30A, Supporting Information). The gene discussed is CD274; the disease is urinary bladder cancer.