In summary, this study highlighted a novel cytoplasm‐enriched lncRNA, BCCE4; we showed that the rs62483508 G > A variant of BCCE4 lost a binding site for miR‐328‐3p, decreased USP18 levels, impaired the stability of PD‐L1, and then attenuated the PD‐L1/PD‐1 interaction, which significantly suppressed bladder cancer progression. This evidence concerns the gene EMSLR and urinary bladder cancer.