However, under less than 25% reduction, Aβ secretion and AD pathology increased that was observed also in hippocampal membranes of rodents or AD patients where disturbation of lipid rafts led to increased APP-BACE1 colocalization outside the rafts and decreased raft-dependent Aβ degradation [169, 317]. This evidence concerns the gene BACE1 and Alzheimer disease.