In 12-month-old APP-KI mice, “cellular homeostasis (GO:0019725)” (median: 1.19-fold), “membrane organization (GO:0061024)” (median: 1.17-fold), and “neutrophil degranulation (R-MMU-6798695)” (median: 1.25-fold) were estimated to be upregulated, and “behavior (GO:0007610)” (median: 0.902-fold) and “prion disease—Mus musculus (house mouse) (mmu05020)” (median: 0.901-fold) were estimated to be downregulated (Fig. 2G). This evidence concerns the gene APP and prion disease.