APP and prion disease: Proteins were also enriched in biological pathways and processes related to “regulation of neuron death (GO:1901214)”, “regulation of cellular response to insulin stimulus (GO:1900076)”, and “glial cell proliferation (GO:0014009)” in 5-month-old APP-KI mice alone and “behavior (GO:0007610)”, “membrane organization (GO:0061024)”, and “prion disease—Mus musculus (house mouse) (mmu05020)” in 12-month-old APP-KI mice alone.