Seventeen of these 42 DPpGC—DEP tandems overlapped with ALS-associated gene annotations in the Harmonizome database, including Cadm2, Cdh4, Cdh13, Ctnna3, Dclk1, Gria3, Grm7, Grm8, Itpr2, Lama3, Macrod2, Plcb1, Prmd16, Ptprn2, Rbfox1, Wwox, and Zbtb20 (Fig. 5A, B; Additional file 7: Table S1), two of which, Macrod2, and Itpr2, also intersected with the human GWAS catalogue (Fig. 5A, B; Additional file 7: Table S1). Here, ITPR2 is linked to amyotrophic lateral sclerosis.