PRDM16 and amyotrophic lateral sclerosis: Apart from the GO enrichment of GPCR, we identified several up-DPpGCs in ALS, Thsd4, Dach1, Wwox, Prdm16, Mgat5, and one miRNA gene, Mir100hg, in the category of CPpGCs in ALS and controls that operate in the antagonization of TGF-β signaling [77, 85–89].