The human IgLON5 family is part of an immunoglobulin superfamily abundantly expressed in neurons, and which is related to the autoimmune-encephalitic and neurodegenerative Anti-IgLON5 syndrome, an important differential diagnosis in motor-neuron disease-like phenotypic presentations involving muscle weakness, stiffness and fasciculations [92–94]. The gene discussed is IGLON5; the disease is motor neuron disorder.