SOD1 and amyotrophic lateral sclerosis: In support, markers of oxidative genomic damage are elevated in body fluids of ALS patients carrying SOD1 mutations [26, 27] and in spinal cord tissue of SOD1G93A mouse mutants [28, 29], while transfection with WT hSOD1 reduces the level of ROS and DNA damage after exposure to H2O2 [7, 23].