CP and amyotrophic lateral sclerosis: Overall, when relating our ALS-specific catalogue of eccDNA hotspot genes to the ALS sub-proteome in the respective cell compartment, we found that the highest percentage of eccDNA releasing genes in ALS had counterparts in the Cysk (2.0%) and sNE (1.4%) fractions, followed by comparable percentages in the CP and cNE fractions (1.3% and 1.2%), and lowest in the ME fraction (0.8%) (Fig. 5D).