TLR2 and Peripheral demyelination: Human and mouse studies have demonstrated that N-glycan branching negatively regulates T cell activity via the T cell receptor (TCR) and B cell antigen presenting cell function via Toll-Like Receptor-2/4 (TLR2/4), thereby suppressing pro-inflammatory T-helper-1 (TH1) and TH17 while enhancing anti-autoimmune T regulatory cell (Treg) responses to inhibit inflammatory demyelination [25–35].