Have a history of Type 1 diabetes, Type 2 diabetes poorly controlled (HbA1c > 6.5% at first visit), type 2 diabetes on insulin, vascular disease, coronary artery disease, stroke, or transient ischemic attack, cancer, organ transplant, bleeding disorder, chronic respiratory disease, including asthma, chronic renal failure, chronic liver disease, or seizure disorder. This evidence concerns the gene INS and asthma.