Gluconeogenesis disorder is the most typical feature of insulin resistance in which HNF-4α synergizes with PGC-1α, FOXO1 and other key enzymes to induce gluconeogenesis [20], and Leptin regulates the AMPK pathway by inhibiting HNF-4α and promoting SIRT1 expression (21). Here, SIRT1 is linked to disorder of gluconeogenesis.