From TCGA analysis (Figure S1A–C, Supporting Information) and qPCR (Figure S1D–F, Supporting Information), and western blot (Figure S1G, Supporting Information) in ESCC tissues collected from five enrolled patients, we found that of these three TAO kinases, TAOK3 was confirmed to be overexpressed in ESCC, and its expression level in ESCC ranked high among all kinds of cancers (Figure S1H, Supporting Information). Here, TAOK3 is linked to esophageal squamous cell carcinoma.