After total RNAs and proteins were isolated from mice tumor tissues, we applied qPCR and western blot assays and found IRGM mRNA and protein were not only downregulated in sh‐IRGM group, but also in sh‐TAOK3 and sh‐ETV5 groups (Figure 6D–L), and the expression of protein IRGM was in positive correlation with TAOK3 or ETV5 (Figure 6M,N), which indicated TAOK3 and ETV5 positively regulated the expression of IRGM. The gene discussed is ETV5; the disease is neoplasm.