In addition to the involvement in the innate immune response, IRGM is well‐known for playing an essential role in regulating autophagy in many types of diseases, including cancers.[26, 27] After the efficiency of ETV5 knockdown and overexpression was confirmed from qPCR (Figure S4A,C, Supporting Information) and western blot assays (Figure S4B,D, Supporting Information), we found that the expression of IRGM was significantly upregulated from the mRNA level when TAOK3 or ETV5 was overexpressed, and downregulated when TAOK3 or ETV5 was knocked down (Figure 3D–G, Supporting Information). Here, IRGM is linked to cancer.