Yu et al. reported a circular RNA, CircMBOAT2, which binds to PTBP1 and protects PTBP1 from ubiquitin/proteasome-dependent degradation, thereby inhibiting the nuclear export of FASN mRNA, promoting lipid metabolism and regulation of redox homeostasis to facilitate ICC progression [25]. Here, PTBP1 is linked to intrahepatic cholangiocarcinoma.