Compared with healthy tissues, the ratios of T cells CD8, T cell CD4 naive, T cells follicular helper, T cells regulatory, Macrophages M0, and Macrophages M1 in CCRCC patients increased significantly, while those of B cells naive, plasma cells, and T cells CD4 memory resting, dendritic cells resting, and mast cells resting significantly reduced (Supplementary Figure S2A). This evidence concerns the gene CD4 and nonpapillary renal cell carcinoma.