IL18 and diabetes mellitus: These data may be due to the impact of diabetes on inflammatory pathways [32]: diabetes leads to a dysregulation of immune pathways such as an alteration in signaling mediated by Toll-like receptors, an alteration in NLR family Pyrin domain containing 3 (NLRP3) inflammasome with the activation of a pro-inflammatory cascade of Il-1β and IL-18 [32], probably increasing immune alteration.