Deglycosylation analysis of MT- and WT-KIT further revealed that KIT localized in the ER (endoglycosidase H-sensitive) was barely detected in GIST and CC cells, which supports the hypothesis that MT-KIT in GISTs is primarily localized in post-ER organelles (Fig. 1E). The gene discussed is KIT; the disease is gastrointestinal stromal tumor.