IKBKG and autosomal dominant hypohidrotic ectodermal dysplasia: A similar situation exists for other X-linked genes such as IKBKG (loss-of-function variants cause incontinentia pigmenti (MIM# 308300) in females; variants with less severe consequences cause hypohidrotic ectodermal dysplasia and immunodeficiency (MIM# 300291) in males) [33].