KIR3DL2 and neoplasm: Two clusters (CL4 and 5), which overlay the cancerous and necrotic regions defined by pathologist annotations, are highlighted by multiple lines of unbiased analyses as carcinoma tumor communities showing differential signatures: CL4, highly proliferative leading-edge vs CL5, core enriched in immune infiltrates interacting with tumor cells and necrotic parts (Fig. 1).