These results raise the possibility that Lpc-EV can be used in the treatment of other brain disorders that are proceeded by reduced expression of neurotrophic factors, TrkB, Mecp2, and Sirt1. Lactobacillus plantarum-derived EVs (Lpl-EV) has the ability to counteract the stress-induced downregulation of neurotrophic factors, MeCP2, and Sirt1 in the brain and improves depressive-like behavioral deficits10,11. This evidence concerns the gene SIRT1 and brain disorder.