TLR3 and COVID-19: Given the risk of neurological “long-COVID” symptoms following SARS-CoV-2 infection21,22, evidence of COVID-induced changes in brain regions that are related to cognition and neurological disorders23, and association of COVID-19 with onset of neurodegenerative disease24, it is highly significant to establish the underlying biological cellular brain responses that are associated with TLR3 activation and viral inflammation.