CRS is a systemic release of inflammatory cytokines following SARS-CoV-2 infection, which includes the release of proinflammatory cytokines like interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), interleukin (IL)−4, IL-6, IL-17A, IL-33, etc22,25,26. This evidence concerns the gene IL33 and congenital rubella syndrome.