However, BA.5 and its parental strain, B.1.1.529, infection leads to the similar frequency of IFN-γ, IL-17A, IL-10-producing CD4+ T cells as well as IFN-γ, IL-10-producing CD8+ T cells in BALF (Fig. 2b & Supplementary Fig. 1d, e). This evidence concerns the gene CD8A and infection.