As shown in Supplementary Fig. S3 and Supplementary Table S8, the expression levels of most APOBEC family members showed a significantly upward trend in ccRCC tumors, including AICDA, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G and APOBEC3H genes (Supplementary Fig. S3A, D–J, respectively). The gene discussed is APOBEC3C; the disease is nonpapillary renal cell carcinoma.