Recent reports have shown that MTHFD2 is also highly expressed in many cancers, including renal clear cell carcinoma76,77, pancreatic cancer,78 breast cancer79, myeloid leukemia80, non-small cell lung cancer81,82, hepatocellular carcinoma83, colorectal cancer84, breast cancer85,86, ovarian cancer87 , bladder cancer88, glioblastoma89, nasopharyngeal carcinoma90, oral squamous cell carcinoma91, and pan-cancer92. This evidence concerns the gene MTHFD2 and cancer.