In summary, the upregulation of BCAT1 and MTHFD2 in ccRCC may be due to the lower levels of hsa-mir-376a_49g and hsa-mir-376c_48g in ccRCC, respectively, which may contribute to the initiation and/or progression of ccRCC. The gene discussed is MTHFD2; the disease is nonpapillary renal cell carcinoma.