As shown in Supplementary Fig. S3 and Supplementary Table S8, the expression levels of most APOBEC family members showed a significantly upward trend in ccRCC tumors, including AICDA, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3D, APOBEC3F, APOBEC3G and APOBEC3H genes (Supplementary Fig. S3A, D–J, respectively). Here, APOBEC3H is linked to nonpapillary renal cell carcinoma.