This approach has been exploited in various entities, such as ALL with t(12;21)/ETV6::RUNX1426,43, ALL with 11q23/KMT2A aberrations446,45, ALL or CML with t(9;22)/BCR::ABL1416,46,47 and other hematopoietic malignancies48–50. The gene discussed is ETV6; the disease is acute lymphoblastic leukemia.