Despite its relative rarity, the translocation is still the third most frequent recurrent chromosomal translocation in ALL (after t(9;22)/BCR::ABL1 and t(4;11)/KMT2A::AFF1 in adult ALL and after t(12;21)/ETV6::RUNX1 and t(4;11)/KMT2A::AFF1 in pediatric ALL)1. The gene discussed is AFF1; the disease is acute lymphoblastic leukemia.