When performing supervised analyses, we observed that SR tumors had trending higher densities of Ly6G+ granulocytes, B220+ B cells, CD11c+ DCs, and CD4+ and CD8+ T cells in all spatial compartments, with significantly higher density of Ly6G+ granulocytes and CD8+ T and DC cells in tumor border and periphery, respectively (Supplemental Fig. S4C–E). This evidence concerns the gene CD8A and neoplasm.