Along with accelerated tumor onset and triple-negative status, Myc;Ptenfl tumors were also more metastatic at the IACUC-defined endpoint, with a 52% and 60% metastasis rate to the lymph node and/or lung, in SR and SP, respectively, compared with only 16% overall metastatic rate for Ptenfl endpoint tumors (Fig. 1H, and Supplement Fig. S1E). This evidence concerns the gene MYC and neoplasm.