The analysis of kinase activity scores inferred from phosphorylation sites by employing PTM signature enrichment analysis34 (Methods), revealed that major kinases activated in papilloma and PUC, such as CDK16, MAP3K8, and TRIB2 were activated in PUC, while RPS6KA2, PRKCG, and IKBKE were activated in papilloma (Fig. 3a). The gene discussed is CDK16; the disease is papilloma.