Pathway enrichment analysis of differentially expressed proteins showed that proteins enriched in PUC were involved in the JAK STAT signaling pathway, mTOCR1 signaling pathway, and DNA repair, whereas proteins enriched in papilloma mainly participated in the P53 pathway, MAPK pathway, and WNT beta catenin signaling pathway (Fig. 3a). This evidence concerns the gene SOAT1 and papilloma.