We next evaluated the frequencies of Tpex and Tex cells by measuring TCF-1 and TIM-3 expression of tumoral WT and Hmgb2−/− P14 T cells and found significantly less Hmgb2−/− Tpex cells compared to WT, similar to our findings during Cl13 infection (Fig. 8c, Fig. 5f, Supplementary Fig. 7a). The gene discussed is TEX46; the disease is infection.