CD69 and neoplasm: Meanwhile, the numbers of CD8+ T cells (Fig. 6e), proliferated CD8+ T cells (Fig. 6f), and activated CD8+CD69+ T cells (Fig. 6g), CD8+IFNγ+ T cells (Fig. 6h) and CD8+GzmB+ T cells (Fig. 6i) were the highest in tumor tissues of R848@M2pep-MPsAFP and anti-PD-1 antibody-treated group.