CD8A and neoplasm: Furthermore, when TAMs isolated from tumor tissues of the above treated orthotopic Hepa1-6 tumor-bearing mice were co-cultured with the CD8+ T cells isolated from the spleens of health C57BL/6 mice for 5 days, the percentages of proliferated CD8+ T cells (Fig. 4f, g), and activated CD8+IFNγ+ T cells (Fig. 4h) and CD8+GzmB+ T cells (Fig. 4i) in R848@M2pep-MPsAFP-treated group were drastically higher than other groups.