Meanwhile, the numbers of stem-like CD8+PD-1+TCF-1+ T cells (Fig. 5j), terminally exhausted CD8+PD-1+TCF-1- T cells (Fig. 5k) and terminally exhausted CD8+ T cells secreting GzmB (CD8+PD-1+TCF-1-GzmB+ T cells, Fig. 5l) in tumor tissues were also remarkably enhanced in R848@M2pep-MPsAFP-treated group. Here, CD8A is linked to neoplasm.