Meanwhile, the numbers of CD8+ T cells (Fig. 8l and Supplementary Fig. 43e), proliferative CD8+ T cells (Fig. 8l and Supplementary Fig. 43f), activated CD8+ T cells (Fig. 8l and Supplementary Fig. 43g–i), stem-like CD8+ T cells (Fig. 8l and Supplementary Fig. 43j), terminally exhausted CD8+ T cells (Fig. 8l and Supplementary Fig. 43k) and terminally exhausted CD8+ T cells secreting GzmB (Fig. 8l and Supplementary Fig. 43l) in tumor tissues were the highest in R848@M2pep-MPsOVA and anti-PD-1 antibody-treated group. Here, CD8A is linked to neoplasm.