CD8A and melanoma: However, no significant difference was detected in the cytotoxicity of CD8+ T cells activated by R848@M2pep-MPs- and R848@M2pep-MPsAFP-reprogrammed M2-like macrophages against murine melanoma B16 cells overexpressing ovalbumin (OVA, B16-OVA cells) (Supplementary Fig. 18h–j).