Meanwhile, the activated CD8+ T cells by R848@M2pep-MPsAFP-reprogrammed M2-like macrophages possessed the strongest cytotoxicity against murine hepatocellular carcinoma Hepa1-6 cells which expressed AFP antigen in an effector/target ratio-dependent manner (Supplementary Fig. 18e–g). The gene discussed is CD8A; the disease is hepatocellular carcinoma.