The role of FLT3 inhibitors in FLT3-ITDhigh AML has been widely established, while controversial results are reported regarding the effects of FLT3 inhibitors on FLT3-ITDlow AML patients receiving chemotherapy.18,41 In our study, sorafenib pre-transplantation improved OS in FLT3-ITDhigh AML patients, but it did not in FLT3-ITDlow AML. Here, FLT3 is linked to acute myeloid leukemia.