PTEN and neoplasm: For example, miR-92a-3p has been shown to inhibit apoptosis and tumor growth in many distinct malignancies by targeting the BH3-only protein BIM and PTEN respectively [23, 27], while promoting cell proliferation by cancer-type specific mechanisms involving targeting of genes such as BTG2 in breast cancer or FBXW7 in renal cancer [39, 45].