Across different cancer types, SV-associated alterations (Fig. 4a and Supplementary Dataset 5) involved Receptor Tyrosine Kinase (RTK) pathway-related genes (EGFR, ERBB2, FGFR2, FGFR3, KRAS, NF1), p53/Rb-related genes (CCND1, CCNE1, CDK4, CDKN2A, E2F3, RB1), TERT, MYC family genes (MYC, MYB, MYCN), and mTOR pathway-related genes (AKT1, PIK3CA, PTEN, STK11). The gene discussed is EGFR; the disease is cancer.