When compared to controls, we observed that most of these markers showed opposite direction of changes in DLB and AD (e.g., CRH, MMP3), three markers had higher levels in DLB (e.g., DDC, GH, PRCP) and six markers had higher levels in AD (e.g., SCD4, TREM1, Fig. 1d). This evidence concerns the gene MMP3 and Lewy body dementia.