Six of these proteins were upregulated in DLB (DDC, GH, IDUA, PRCP, KYNU, and ENTPD5) and eight proteins were downregulated (CRH, FCER2, MMP1, COL4A1, WIF1, PAM, VEGFA and CTSC, Fig. 1b, Supplementary Dataset 1). This evidence concerns the gene WIF1 and Lewy body dementia.