Six of these proteins were upregulated in DLB (DDC, GH, IDUA, PRCP, KYNU, and ENTPD5) and eight proteins were downregulated (CRH, FCER2, MMP1, COL4A1, WIF1, PAM, VEGFA and CTSC, Fig. 1b, Supplementary Dataset 1). Here, CRH is linked to Lewy body dementia.