HDAC9 and cancer: With regard to the biological implications of (R)-lipoic acid inhibition of HDAC isozymes, Lechner et al. (17) report that both (R)-lipoic acid and (R)-lipoamide inhibit stress granule formation in cancer cells, an effect that has also been observed for other HDAC inhibitors such as Trichostatin and Tubastatin (47).