AR and Familial prostate cancer: de Petrocellis et al. showed thatCBD induced cell death through increased apoptosis in androgen-sensitiveLNCaP cells, partly mediated through antagonism of the ion channeltransient receptor potential metastatin 8 (TRPM8), which is involvedin androgen receptor (AR)-dependent prostate cancer cell survival.8 The CBD-induced apoptosis was accompanied byincreased reactive oxygen species production, increased levels ofp53 upregulated modulator of apoptosis (PUMA), C/EBP homologous protein(CHOP), and intracellular calcium, activation of p53, and downregulationof AR.