TP53 and Familial prostate cancer: For example, CBDinduced cell cycle arrest in pancreatic cancer cells by inhibitingextracellular signal-related kinase (ERK) phosphorylation and reducingcyclin D expression.15 In gastric cancercells, CBD reduced proliferation by modulating p21 and p53 expression,leading to inhibition of CDK2/cyclin E complex formation.5 In breast cancer and multiple myeloma cells,CBD inhibited proliferation through reduced phosphorylation and activationof ERK and AKT.3,18 In prostate cancer, studies havereported antiproliferative effects of synthetic cannabinoids.