For example, CBDinduced cell cycle arrest in pancreatic cancer cells by inhibitingextracellular signal-related kinase (ERK) phosphorylation and reducingcyclin D expression.15 In gastric cancercells, CBD reduced proliferation by modulating p21 and p53 expression,leading to inhibition of CDK2/cyclin E complex formation.5 In breast cancer and multiple myeloma cells,CBD inhibited proliferation through reduced phosphorylation and activationof ERK and AKT.3,18 In prostate cancer, studies havereported antiproliferative effects of synthetic cannabinoids. Here, TP53 is linked to prostate cancer.