Critically, these patients carry pathogenic mutations covering a range of autosomal dominant polycystic liver (SEC63 and PRKCSH) and kidney (PKD1 and PKD2) disease-related genes, suggesting that the acquisition of integrin-α2β1 mediated-sensing of the microenvironment may be a common mechanism during cyst formation across pathologies regardless of the underlying genetics. Here, PRKCSH is linked to cyst.