The pSer356 phosphorylation site, in the microtubule-binding domain of tau, was suggested to reflect an early pathological event in tau phosphorylation and aggregation.40 Its expression compared to controls was the highest of all tau epitopes, with the greatest in FTLD-MAPT and lower in PiD > PSP, in contrast to the pattern of proline-rich region epitopes. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.