Pre-clinical models of tau pathology reported activation of microglia and astrocytes together with upregulation of pro-inflammatory cytokines11-14 and post-mortem studies identified microglial activation in human tauopathies.15,16 Evidence supports the concept that neuroinflammation might precede tau pathology, as observed in mice17 and in a human TSPO-PET study,18 consistent with the glial cell activation identified in several neurodegenerative conditions.19 Here, MAPT is linked to tauopathy.