However, some studies have shown increased 11C-PK11195 binding in subcortical regions of clinically diagnosed PSP patients55 as well as in the frontal lobe.56 A study combining PET imaging for microglia and tau detected an association between neuroinflammation (11C-PK-11195) and tau deposition (18F-AV-1451) in FTD.57 Being an in vivo study, the patients were not stratified by the subtype of the FTLD (e.g. tau, TDP43). The gene discussed is TARDBP; the disease is frontotemporal dementia.