MAPT and tauopathy: In contrast, PiD is uniquely associated with spherical tau inclusions in neurons, called Pick bodies, with other features displayed being Pick cells/ballooned neurons and tau-positive astrocytes, which are noted as being ramified in structure.4,5 The pattern of tau phosphorylation in tauopathies has been reported previously in small cohorts of FTLD-tau (n = 3–8) using a semi-quantitative scale,6 but it remains to be confirmed whether there are any disease-specific differences in the amount of tau.