HMGB1 and infection: Upon infection with human adenovirus type 5 (Ad5), we observed that the HMGB1 constructs had three different localization patterns: a diffusely nuclear pattern similar to that of mock infection (Fig 2C, triangle), a ring-like pattern, referred to as pattern I (Fig 2C, circle), or a punctate pattern, referred to as pattern II (Fig 2C, star).