The second most influential parameter for PH and CKD cases avoided was RRR (range) associated with an increase in Hb ≥1 g/dL: 0.43 (0.32–0.054) for PH (Fig 6B) and 0.47 (0.35–0.59) for CKD (Fig 6C). The gene discussed is GSTM1; the disease is chronic kidney disease.