For the predicted number of strokes avoided, the most influential parameter was RRR for stroke (0.59 [0.44–0.74]), with a range of −27.9% to −11.9% (base case of –19.8%), followed by Hb response and treatment continuation, with a range of −25.2% to −13.0% (Fig 6D). This evidence concerns the gene GSTM1 and Stroke.