Based on a one-way deterministic sensitivity analysis, the most influential parameters for avoidance of the number of deaths, PH and CKD cases, and strokes included the adoption and diffusion patterns of voxelotor, Hb levels achieved in response to treatment with voxelotor and voxelotor treatment adherence, as well as RRR estimates for each disease complication. The gene discussed is GSTM1; the disease is chronic kidney disease.