For predicted PH and CKD cases avoided, the most influential parameter was Hb response and treatment continuation, with ranges of −32.6% to −15.3% for PH cases avoided (base case of −24.5%) and −32.4% to −16.3% for CKD cases avoided (base case of −25.1%) (Fig 6B and 6C, respectively). The gene discussed is GSTM1; the disease is chronic kidney disease.