Ghareghani et al. (14) examined the influence of vitamin D, melanopsin, pineal gland, intestinal calcium, intestinal endotoxins (lipopolysaccharides; LPS), and CD14/TLR4 in neurologic diseases, and found that low vitamin D levels and impaired intestinal calcium absorption could lead to migration of LPS to the brain and trigger the release of proinflammatory cytokines via the CD14/TLR4/MD2 complex. This evidence concerns the gene OPN4 and nervous system disorder.